Hydrogen Bromide → 6-(Bromomethyl)-2,4-diaminopyrido [2,3-d]pyrimidine

HRID 1735132

반응식

HRID 1735132 반응식
[NH2:1][C:2]1[N:3]=[C:4]([NH2:14])[C:5]2[CH:11]=[C:10]([CH2:12]O)[CH:9]=[N:8][C:6]=2[N:7]=1.[BrH:15]>CC(O)=O>[Br:15][CH2:12][C:10]1[CH:9]=[N:8][C:6]2[N:7]=[C:2]([NH2:1])[N:3]=[C:4]([NH2:14])[C:5]=2[CH:11]=1

참가 물질

4

반응물 2

HCID 260Hydrogen BromideHCID 4874162,4-Diamino-6-(hydroxymethyl)pyrido[2,3-d]pyrimidine

생성물 1

HCID 105628616-(Bromomethyl)-2,4-diaminopyrido [2,3-d]pyrimidine

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

The intermediate III-2 was prepared from 2,4-diaminopyrido [2,3-d]pyrimidine-6-methanol (III-1) by the procedure described in J. Med. Chem., 35:332 (1992). This particular preparation analyzed for a 1.75 HBr° 0.25 CH3COOH salt (formula wt. 406.7). The material was suitable for conversions to compound 33.

후처리

  1. customThis particular preparation

출처 및 근거

ORD 기록
ord-4519af7ad0c042d9b7c1e74387c6d76a
출처 데이터셋
uspto-grants-1996_07
특허 번호
US05536724

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