Hydrochloric Acid → 2-(Thymin-1-ylcarbonylamino)-5-(t-butyloxycarbonyl-amino)pentanoic acid

HRID 1735949노트

반응식

HRID 1735949 반응식
C([O:3][C:4](=[O:29])[CH:5]([NH:17][C:18]([N:20]1[CH:28]=[C:26]([CH3:27])[C:24](=[O:25])[NH:23][C:21]1=[O:22])=[O:19])[CH2:6][CH2:7][CH2:8][NH:9][C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])C.Cl>C(O)C.[OH-].[Na+]>[N:20]1([C:18]([NH:17][CH:5]([CH2:6][CH2:7][CH2:8][NH:9][C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[C:4]([OH:29])=[O:3])=[O:19])[CH:28]=[C:26]([CH3:27])[C:24](=[O:25])[NH:23][C:21]1=[O:22]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 54034076HCID 54034076, 화합물

생성물 1

HCID 190762582-(Thymin-1-ylcarbonylamino)-5-(t-butyloxycarbonyl-amino)pentanoic acid

시약·촉매·용매 2

HCID 702Ethanol용매HCID 14798Sodium Hydroxide용매

실험 절차

The product from Example 11, 15, is dissolved in ethanol (500 mL) and to this added 2M sodium hydroxide (50 mL) and the reaction stirred for 12 hours. The reaction is neutralized with 2M HCl solution (50 mL) and evaporated to a small volume. This residue is diluted with water (250 mL) and extracted with dichloromethane (4×100 mL), dried, filtered, and evaporated to give a solid.

후처리

  1. customevaporated to a small volume
  2. additionThis residue is diluted with water (250 mL)
  3. extractionextracted with dichloromethane (4×100 mL)
  4. customdried
  5. filtrationfiltered
  6. customevaporated
  7. customto give a solid

출처 및 근거

ORD 기록
ord-505deacc5ea842da833a8b854e216329
출처 데이터셋
uspto-grants-1996_07
특허 번호
US05539082

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