Methyl iodide → Ethyl 2-methoxyisonicotinate
반응식
[OH:1][C:2]1[CH:7]=[C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH:5]=[CH:4][N:3]=1.[CH3:13]I>C1(C)C=CC=CC=1.C(=O)([O-])[O-].[Ag+].[Ag+]>[CH3:13][O:1][C:2]1[CH:7]=[C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH:5]=[CH:4][N:3]=1참가 물질
5
실험 절차
A mixture of ethyl 2-hydroxy-pyridine-4-carboxylate (1.0 g, 6 mmol), (Chem. Abs. 1957, 8740c), methyl iodide (1 ml) and silver(I)carbonate (1.64 g) in toluene (20 ml) was heated at reflux for 2 hours. The mixture was allowed to cool and the insolubles removed by filtration through diatomaceous earth and the pad was washed through with ethyl acetate. The filtrate was washed with water, dried (MgSO4) and the solvent removed by evaporation to give ethyl 2-methoxy-pyridine-4-carboxylate (0.93 g, 86%) as a yellow oil.
후처리
- temperaturewas heated
- temperatureat reflux for 2 hours
- temperatureto cool
- customthe insolubles removed by filtration through diatomaceous earth
- washthe pad was washed through with ethyl acetate
- washThe filtrate was washed with water
- dry with materialdried (MgSO4)
- customthe solvent removed by evaporation
출처 및 근거
- ORD 기록
- ord-a986088963044d95ada1cc7f125f87f2
- 출처 데이터셋
- uspto-grants-1999_10
- 특허 번호
- US05962458
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