Hydrochloric Acid → HCID 178447284, 화합물

HRID 1739080노트

반응식

[NH:1]1[C:5]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[C:12]2[CH:17]=[CH:16][C:15]([CH2:18][N:19]([C:29](=O)[CH2:30][CH2:31][CH2:32][CH3:33])[C:20]3(C([O-])=O)[CH2:24][CH2:23][CH2:22][CH:21]3[CH3:25])=[CH:14][CH:13]=2)=[N:4][N:3]=[N:2]1.[OH-:35].[Na+].Cl.C(Cl)Cl.[CH3:41][OH:42].C([OH:45])C>>[NH:1]1[C:5]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[C:12]2[CH:13]=[CH:14][C:15]([CH2:18][N:19]([CH2:20][C:24]3([C:41]([OH:45])=[O:42])[CH2:25][CH2:21][CH2:22][CH2:23]3)[C:29](=[O:35])[CH2:30][CH2:31][CH2:32][CH3:33])=[CH:16][CH:17]=2)=[N:4][N:3]=[N:2]1

참가 물질

반응물 5

HCID 313Hydrochloric Acid

HCID 702Ethanol

HCID 14798Sodium Hydroxide

HCID 21226129Dichloromethane methanol

HCID 178447282HCID 178447282, 화합물

생성물 1

HCID 178447284HCID 178447284, 화합물

실험 절차

0.979 g of N-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-N-valeryl-1-amino-methylcyclopentane-1-carboxylate are dissolved in 10 ml of ethanol and treated with 4 ml of 2N NaOH solution, and the mixture is heated to reflux for 23 h. After cooling to room temperature and adding 4.5 ml of 2N hydrochloric acid, the mixture is evaporated and the product is isolated by chromatography on silica gel 60 (40-63 μm) using CH2Cl2 --MeOH 95:5, Rf =0.35 (system N8). MS (FAB): m/e 462 (M+ +H).

후처리

temperaturethe mixture is heated
temperatureto reflux for 23 h
customthe mixture is evaporated
customthe product is isolated by chromatography on silica gel 60 (40-63 μm)

출처 및 근거

ORD 기록: ord-901f824275714f8087597d3fa7f5e077
출처 데이터셋: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05965592

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