Acetanilide → Aniline, 2,4-difluoro-6-nitro-

HRID 1739539노트

반응식

[F:1][C:2]1[CH:8]=[C:7]([F:9])[CH:6]=[CH:5][C:3]=1[NH2:4].C(OC(=O)C)(=O)C.C(NC1C=CC=CC=1)(=O)C.[N+:27]([O-])([OH:29])=[O:28].OS(O)(=O)=O>>[F:1][C:2]1[CH:8]=[C:7]([F:9])[CH:6]=[C:5]([N+:27]([O-:29])=[O:28])[C:3]=1[NH2:4]

참가 물질

반응물 4

HCID 904Acetanilide

HCID 7918Acetic Anhydride

HCID 97092,4-Difluoroaniline2회

HCID 71777668Sulfuric acid, mixt. with nitric acid

생성물 1

HCID 9697Aniline, 2,4-difluoro-6-nitro-

실험 절차

Thus WO 96/02493, starting from 2,4-difluoroaniline, discloses a synthesis proceeding via five stages. 2,4-Difluoroaniline is first reacted with acetic anhydride, the resulting acetanilide is nitrated by means of HNO3 /H2SO4, the acetyl radical is removed and 2,4-difluoro-6-nitroaniline is obtained. By reaction of the 2,4-difluoro-6-nitroaniline with sodium nitrite, the amino group can be removed and 3,5-difluoronitrobenzene is obtained, which can be converted into 3,5-difluoroaniline by reduction.

후처리

customthe acetyl radical is removed

출처 및 근거

ORD 기록: ord-a381ac1090724e748c12032d0170d0cc
출처 데이터셋: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05965775

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