L-Phenylglycine → (alphaS)-alpha-Aminocyclohexaneacetic acid
반응식
[CH:1]1[CH:6]=[CH:5][C:4]([C@H:7]([NH2:11])[C:8]([OH:10])=[O:9])=[CH:3][CH:2]=1>C(O)(=O)C.O=[Pt]=O>[NH2:11][C@@H:7]([CH:4]1[CH2:5][CH2:6][CH2:1][CH2:2][CH2:3]1)[C:8]([OH:10])=[O:9]참가 물질
4
실험 절차
L-Phenylglycine (8.04 g, 53 mmol) was reduced by catalytic hydrogenation using PtO2 in 80% acetic acid (HOAc) (200 mL). The catalyst was removed by filtration and the HOAc removed under reduced pressure to afford the title compound as a white solid (7.8 g, 94%). The 300 MHz 1H NMR spectrum was found to be consistent with the proposed structure.
후처리
- customThe catalyst was removed by filtration
- customthe HOAc removed under reduced pressure
출처 및 근거
- ORD 기록
- ord-e53c6e87187a4405aa1d64ff3b823b56
- 출처 데이터셋
- uspto-grants-1994_08
- 특허 번호
- US05338726
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