L-Phenylglycine → (alphaS)-alpha-Aminocyclohexaneacetic acid

HRID 1742204

반응식

HRID 1742204 반응식
[CH:1]1[CH:6]=[CH:5][C:4]([C@H:7]([NH2:11])[C:8]([OH:10])=[O:9])=[CH:3][CH:2]=1>C(O)(=O)C.O=[Pt]=O>[NH2:11][C@@H:7]([CH:4]1[CH2:5][CH2:6][CH2:1][CH2:2][CH2:3]1)[C:8]([OH:10])=[O:9]

참가 물질

4

반응물 1

HCID 99291L-Phenylglycine

생성물 1

HCID 736848(alphaS)-alpha-Aminocyclohexaneacetic acid수율 94%

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매HCID 176Acetic Acid용매

실험 절차

L-Phenylglycine (8.04 g, 53 mmol) was reduced by catalytic hydrogenation using PtO2 in 80% acetic acid (HOAc) (200 mL). The catalyst was removed by filtration and the HOAc removed under reduced pressure to afford the title compound as a white solid (7.8 g, 94%). The 300 MHz 1H NMR spectrum was found to be consistent with the proposed structure.

후처리

  1. customThe catalyst was removed by filtration
  2. customthe HOAc removed under reduced pressure

출처 및 근거

ORD 기록
ord-e53c6e87187a4405aa1d64ff3b823b56
출처 데이터셋
uspto-grants-1994_08
특허 번호
US05338726

연결된 노트

불러오는 중…