Hydrogen Bromide → HCID 178444239, 화합물

HRID 1742777노트

반응식

HRID 1742777 반응식
P(Br)(Br)Br.[BrH:5].[CH2:6]([C@H:11]1[CH2:16][CH2:15][C@H:14](O)[CH2:13][CH2:12]1)[CH2:7][CH2:8][CH2:9][CH3:10]>O>[CH2:6]([C@H:11]1[CH2:16][CH2:15][C@H:14]([Br:5])[CH2:13][CH2:12]1)[CH2:7][CH2:8][CH2:9][CH3:10]

참가 물질

5

반응물 3

HCID 260Hydrogen BromideHCID 24614Phosphorus tribromideHCID 178444573HCID 178444573, 화합물

생성물 1

HCID 178444239HCID 178444239, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a mixture of 104 g of phosphorus tribromide and 5 drops of a 48% aqueous solution of hydrogen bromide, 138 g of trans-4-pentylcyclohexanol were added dropwise under stirring while the temperature was controlled below 10° C. After the completion of the dropwise addition, the reaction mixture was reacted for one hour at the same temperature and then at room temperature for additional 1 hour. After the completion of the reaction, the reaction mixture was added with 200 ml of water, followed by extraction with diethyl ether. After the extract was washed with saturated NaCl, anhydrous sodium sulfate was added to dry the extract. The resultant mixture was filtered and the solvent was distilled off from the filtrate under reduced pressure, whereby trans-4-pentylcyclohexyl bromide was obtained.

후처리

  1. additionwere added dropwise
  2. customwas controlled below 10° C
  3. additionAfter the completion of the dropwise addition
  4. customthe reaction mixture was reacted for one hour at the same temperature
  5. customAfter the completion of the reaction
  6. extractionfollowed by extraction with diethyl ether
  7. washAfter the extract was washed with saturated NaCl, anhydrous sodium sulfate
  8. additionwas added
  9. customto dry the extract
  10. filtrationThe resultant mixture was filtered
  11. distillationthe solvent was distilled off from the filtrate under reduced pressure

출처 및 근거

ORD 기록
ord-67b9ec694ab648a58c81134ea557fb07
출처 데이터셋
uspto-grants-1994_08
특허 번호
US05342546

반응 노트

불러오는 중…