Hydrochloric Acid → HCID 28354564, 화합물

HRID 1744057노트

반응식

HRID 1744057 반응식
[Br:1][C:2]1[CH:18]=[CH:17][C:5]([CH2:6][NH:7][C@@H:8]([CH2:13][CH:14]([CH3:16])[CH3:15])[C:9]([O:11]C)=[O:10])=[CH:4][CH:3]=1.[Li+].[OH-].Cl>CO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][NH:7][C@@H:8]([CH2:13][CH:14]([CH3:15])[CH3:16])[C:9]([OH:11])=[O:10])=[CH:17][CH:18]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 86594553HCID 86594553, 화합물

생성물 1

HCID 28354564HCID 28354564, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To methyl (2S)-2-[(4-bromobenzyl)amino]-4-methylpentanoate (2.198 g, 7.0 mmol) in MeOH (30 mL) was added an aqueous solution of LiOH (2 M, 17.5 mL, 35 mmol) and the reaction was stirred overnight. The reaction was neutralized with aqueous 10% HCl (pH of 6–7) and the product crystallized out of solution and was filtered and dried in vacuo to afford (2S)-2-[(4-bromobenzyl)amino]-4-methylpentanoic acid.

후처리

  1. customthe product crystallized out of solution
  2. filtrationwas filtered
  3. customdried in vacuo

출처 및 근거

ORD 기록
ord-27630d94e7314f20af4009d83d8fa504
출처 데이터셋
uspto-grants-2006_03
특허 번호
US07012075B2

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