Hydrochloric Acid → 5-methyl-1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxylic acid

HRID 1748271노트

반응식

HRID 1748271 반응식
[OH-].[Na+].[CH3:3][CH:4]1[N:10]2[C:11]3[CH:12]=[C:13]([C:18]([O:20]CC)=[O:19])[CH:14]=[CH:15][C:16]=3[CH:17]=[C:9]2[C:8](=[O:23])[NH:7][CH2:6][CH2:5]1.Cl>C(O)C>[CH3:3][CH:4]1[N:10]2[C:11]3[CH:12]=[C:13]([C:18]([OH:20])=[O:19])[CH:14]=[CH:15][C:16]=3[CH:17]=[C:9]2[C:8](=[O:23])[NH:7][CH2:6][CH2:5]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67235486ethyl 5-methyl-1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxylate

생성물 1

HCID 672353965-methyl-1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxylic acid수율 93.6%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

1 NaOH solution (60 mL, 60 mmol) is added to a solution of ethyl 5-methyl-1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxylate (7.0 g, 24 mmol) in ethanol (75 mL). The reaction mixture is refluxed for 1.5 h. Then the reaction mixture is acidified with 1M HCl and ethanol is removed under vacuum. The resulting solid is filtered, washed with water and dried to afford the title compound (5.8 g, 92%) as a solid.

후처리

  1. temperatureThe reaction mixture is refluxed for 1.5 h
  2. customis removed under vacuum
  3. filtrationThe resulting solid is filtered
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-b4099f8b93fd4d88b2fd38f6f876c00e
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09150577B2

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