Hydrochloric Acid → 1-(4-Ethoxyphenyl)-5-methyl-1H-pyrazole-4-carboxylic acid

HRID 1748456노트

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HRID 1748456 반응식
[OH-].[Na+].C([O:5][C:6]([C:8]1[CH:9]=[N:10][N:11]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH3:22])=[CH:16][CH:15]=2)[C:12]=1[CH3:13])=[O:7])C.Cl>C(O)C>[CH2:21]([O:20][C:17]1[CH:16]=[CH:15][C:14]([N:11]2[C:12]([CH3:13])=[C:8]([C:6]([OH:7])=[O:5])[CH:9]=[N:10]2)=[CH:19][CH:18]=1)[CH3:22]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 866924251-(4-ethoxyphenyl)-5-methyl-1H-pyrazole-4-carboxylic acid ethyl ester

생성물 1

HCID 820860711-(4-Ethoxyphenyl)-5-methyl-1H-pyrazole-4-carboxylic acid수율 96%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
70 °C

실험 절차

1N Aqueous solution of sodium hydroxide (4.8 ml) was added to a solution of 1-(4-ethoxyphenyl)-5-methyl-1H-pyrazole-4-carboxylic acid ethyl ester (1.3 g) in ethanol (24 ml) at room temperature and stirred at 70° C. for three hours. After completion of the reaction, the reaction solution was cooled to room temperature, 1N hydrochloric acid aqueous solution was added and the precipitated solid was collected by filtration to give the titled compound (1.12 g) as a white solid.

후처리

  1. customAfter completion of the reaction
  2. temperaturethe reaction solution was cooled to room temperature
  3. filtrationthe precipitated solid was collected by filtration

출처 및 근거

ORD 기록
ord-bcec41ce361f4bf18ebf05da1ae0e7dc
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09150555B2

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