Sodium Hydroxide → 1-(4-Methoxyphenyl)pyrrole-3-carboxylic acid

HRID 1748487노트

반응식

HRID 1748487 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH:13]=[CH:12][C:11]([CH:14]=[O:15])=[CH:10]2)=[CH:5][CH:4]=1.[OH-].[Na+].[Mn]([O-])(=O)(=O)=[O:19].[K+]>N1C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N:9]2[CH:13]=[CH:12][C:11]([C:14]([OH:19])=[O:15])=[CH:10]2)=[CH:7][CH:8]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 516875Potassium PermanganateHCID 105599931-(4-methoxyphenyl)-1H-pyrrole-3-carbaldehyde

생성물 1

HCID 685730691-(4-Methoxyphenyl)pyrrole-3-carboxylic acid

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

Next, 1-(4-methoxyphenyl)pyrrole-3-carbaldehyde was added to an aqueous solution (100 ml) of sodium hydroxide (4.38 g) and an aqueous pyridine solution (water 100 ml and pyridine 180 ml) of potassium permanganate (8.65 g) at 20-30° C., and stirred at room temperature for six hours. After completion of the reaction, the reaction solution was filtered through Celite, the filtrate was acidified by the addition of hydrochloric acid and extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, concentrated in vacuo and the precipitated solid was purified with ethyl acetate/n-hexane to give the titled compound (8.52 g).

후처리

  1. customAfter completion of the reaction
  2. filtrationthe reaction solution was filtered through Celite
  3. additionthe filtrate was acidified by the addition of hydrochloric acid
  4. extractionextracted with ethyl acetate
  5. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  6. concentrationconcentrated in vacuo
  7. customthe precipitated solid was purified with ethyl acetate/n-hexane

출처 및 근거

ORD 기록
ord-3cd4ab85432045039c01e8401cd8225d
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09150555B2

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