Methanol → N-[6-(4-Hydroxycyclohex-1-en-1-yl)-5-methylpyridin-3-yl]-5-methyl-1-[4-(trifluoromethyl)-phenyl]-1H-pyrazole-4-carboxamide

HRID 1748647노트

반응식

HRID 1748647 반응식
[BH4-].[Na+].[CH3:3][C:4]1[CH:5]=[C:6]([NH:17][C:18]([C:20]2[CH:21]=[N:22][N:23]([C:25]3[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][CH:26]=3)[CH:24]=2)=[O:19])[CH:7]=[N:8][C:9]=1[C:10]1[CH2:15][CH2:14][C:13](=[O:16])[CH2:12][CH:11]=1.[OH-].[Na+].[CH3:37]O>>[OH:16][CH:13]1[CH2:14][CH2:15][C:10]([C:9]2[N:8]=[CH:7][C:6]([NH:17][C:18]([C:20]3[CH:21]=[N:22][N:23]([C:25]4[CH:26]=[CH:27][C:28]([C:31]([F:34])([F:32])[F:33])=[CH:29][CH:30]=4)[C:24]=3[CH3:37])=[O:19])=[CH:5][C:4]=2[CH3:3])=[CH:11][CH2:12]1

참가 물질

5

반응물 4

HCID 887MethanolHCID 14798Sodium HydroxideHCID 4311764Sodium borohydrideHCID 86692586N-[5-methyl-6-(4-oxocyclohex-1-en-1-yl)pyridin-3-yl]-1-[4-(trifluoromethyl)phenyl]-1H-pyrazole-4-carboxamide

생성물 1

HCID 86692587N-[6-(4-Hydroxycyclohex-1-en-1-yl)-5-methylpyridin-3-yl]-5-methyl-1-[4-(trifluoromethyl)-phenyl]-1H-pyrazole-4-carboxamide

실험 절차

Sodium borohydride (19 mg) was added to a solution of N-[5-methyl-6-(4-oxocyclohex-1-en-1-yl)pyridin-3-yl]-1-[4-(trifluoromethyl)phenyl]-1H-pyrazole-4-carboxamide (114 mg) in methanol (15 ml) under ice-cooling and the mixture was stirred at the same temperature for 30 minutes. After the reaction, 1N aqueous solution of sodium hydroxide was added and the organic solvent was evaporated. The precipitated solid was washed with water, filtered and dried at 60° C. under current of air to give the titled compound (110 mg) as a white solid.

후처리

  1. temperaturecooling
  2. additionwas added
  3. customthe organic solvent was evaporated
  4. washThe precipitated solid was washed with water
  5. filtrationfiltered
  6. customdried at 60° C. under current of air

출처 및 근거

ORD 기록
ord-96899710458242b6a27b7b48bbebeaad
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09150555B2

반응 노트

불러오는 중…