Sodium Thiosulfate → 2-(2-ethylsulfonyl-4-trifluoromethylsulfanylphenyl)3-methyl-6-pentafluoroethyl-3H-imidazo[4,5-b]pyridine

HRID 1750061노트

반응식

HRID 1750061 반응식
Cl[C:2]1C=C(C=C[CH:11]=1)C(OO)=O.C(S[C:15]1[CH:20]=[C:19]([S:21][C:22]([F:25])([F:24])[F:23])[CH:18]=[CH:17][C:16]=1[C:26]1[N:41]([CH3:42])[C:29]2=[N:30][CH:31]=[C:32]([C:34]([F:40])([F:39])[C:35]([F:38])([F:37])[F:36])[CH:33]=[C:28]2[N:27]=1)C.C(=O)(O)[O-].[Na+].[S:48]([O-:52])([O-])(=[O:50])=S.[Na+].[Na+]>C(Cl)(Cl)Cl>[CH2:2]([S:48]([C:15]1[CH:20]=[C:19]([S:21][C:22]([F:23])([F:25])[F:24])[CH:18]=[CH:17][C:16]=1[C:26]1[N:41]([CH3:42])[C:29]2=[N:30][CH:31]=[C:32]([C:34]([F:40])([F:39])[C:35]([F:36])([F:37])[F:38])[CH:33]=[C:28]2[N:27]=1)(=[O:52])=[O:50])[CH3:11]

참가 물질

6

반응물 4

HCID 24477Sodium ThiosulfateHCID 70297m-Chloroperbenzoic acidHCID 516892Sodium BicarbonateHCID 1180356092-(2-ethylsulfanyl-4-trifluoromethylsulfanylphenyl)3-methyl-6-pentafluoroethyl-3H-imidazo[4,5-b]pyridine

생성물 1

HCID 1180355032-(2-ethylsulfonyl-4-trifluoromethylsulfanylphenyl)3-methyl-6-pentafluoroethyl-3H-imidazo[4,5-b]pyridine

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

0.19 g of 3-chloroperoxybenzoic acid (purity of 65% or more) was added to a mixture of 0.19 g of 2-(2-ethylsulfanyl-4-trifluoromethylsulfanylphenyl)3-methyl-6-pentafluoroethyl-3H-imidazo[4,5-b]pyridine and 3 ml of chloroform under ice cooling, and then the mixture was stirred under ice cooling for 2 hours. A saturated aqueous sodium bicarbonate solution and a saturated aqueous sodium thiosulfate solution were added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and then concentrated under reduced pressure. The resulting residue was applied to a silica gel column chromatography to obtain 0.22 g of 2-(2-ethylsulfonyl-4-trifluoromethylsulfanylphenyl)3-methyl-6-pentafluoroethyl-3H-imidazo[4,5-b]pyridine (hereinafter, referred to as Compound 10).

후처리

  1. extractionthe mixture was extracted with ethyl acetate
  2. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-e34b96037c8f42c0a8246e4a54ac848a
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09156838B2

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