Hydrochloric Acid → 3-Cyclopropylpicolinic acid

HRID 1750486노트

반응식

HRID 1750486 반응식
[CH:1]1([C:4]2[C:5]([C:10]([O:12]C)=[O:11])=[N:6][CH:7]=[CH:8][CH:9]=2)[CH2:3][CH2:2]1.[OH-].[Li+].Cl>C1COCC1.O>[CH:1]1([C:4]2[C:5]([C:10]([OH:12])=[O:11])=[N:6][CH:7]=[CH:8][CH:9]=2)[CH2:2][CH2:3]1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 68687300Methyl 3-cyclopropylpyridine-2-carboxylate

생성물 1

HCID 686851453-Cyclopropylpicolinic acid

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of methyl 3-cyclopropylpyridine-2-carboxylate (80 mg, 0.45 mmol) in THF (2 ml) and water (2 ml) was added lithium hydroxide (55 mg, 1.36 mmol) and the reaction mixture was refluxed for 2 hours. The reaction was then acidified to pH 2 using 1M HCl (aq) and extracted with DCM (3×50 ml). The combined organics were washed with water (30 ml), brine (30 ml), dried over sodium sulfate and concentrated in vacuo to afford the title compound.

후처리

  1. temperaturethe reaction mixture was refluxed for 2 hours
  2. extractionextracted with DCM (3×50 ml)
  3. washThe combined organics were washed with water (30 ml), brine (30 ml)
  4. dry with materialdried over sodium sulfate
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-802bb63e6c1745ac80524b9fa1ec178f
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09156829B2

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