Hydrochloric Acid → 3-Amino-5-(2-methoxy-ethyl)-pyrazine-2-carboxylic acid

HRID 1752504노트

반응식

HRID 1752504 반응식
C[O:2][C:3]([C:5]1[C:10]([NH2:11])=[N:9][C:8]([CH2:12][CH2:13][O:14][CH3:15])=[CH:7][N:6]=1)=[O:4].[OH-].[Na+].Cl>C1COCC1>[NH2:11][C:10]1[C:5]([C:3]([OH:4])=[O:2])=[N:6][CH:7]=[C:8]([CH2:12][CH2:13][O:14][CH3:15])[N:9]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 712711513-Amino-5-(2-methoxy-ethyl)-pyrazine-2-carboxylic acid methyl ester

생성물 1

HCID 866891713-Amino-5-(2-methoxy-ethyl)-pyrazine-2-carboxylic acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 3-amino-5-(2-methoxy-ethyl)-pyrazine-2-carboxylic acid methyl ester (147 mg, 0.696 mmol) in THF (14 ml) was added 1M NaOH (1.74 ml, 1.74 mmol) and the reaction mixture was stirred at room temperature for 2 h. 1M HCl (1.601 ml, 1.601 mmol) was added to the reaction mixture. The resulting mixture was evaporated and co-evaporated with toluene. The resulting crude material was directly used in the coupling step without further purification.

후처리

  1. customThe resulting mixture was evaporated
  2. customThe resulting crude material was directly used in the coupling step without further purification

출처 및 근거

ORD 기록
ord-34bc511b2fed4638b82eb139e05c4c6b
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09163011B2

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