Ethyl orthoformate → Ethyl 2-(ethoxymethylene)-4,4,4-trifluoroacetoacetate
반응식
[F:1][C:2]([F:12])([F:11])[C:3](=[O:10])[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH2:13]([O:15][CH:16](OCC)OCC)[CH3:14]>C(OC(=O)C)(=O)C>[CH2:13]([O:15]/[CH:16]=[C:4](/[C:3](=[O:10])[C:2]([F:11])([F:12])[F:1])\[C:5]([O:7][CH2:8][CH3:9])=[O:6])[CH3:14]참가 물질
4
실험 절차
To a solution of ethyl 4,4,4-trifluoro-3-oxobutanoate (20 g, 108.63 mmol) in acetic anhydride (39 mL) was added triethylorthoformate (54.2 mL, 325.89 mmol) and the reaction heated to reflux for 18 hours. The reaction was cooled, concentrated in vacuo and used directly in the next step.
후처리
- temperaturethe reaction heated
- temperatureto reflux for 18 hours
- temperatureThe reaction was cooled
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-c4d1ba12b2db4c698f4e8d65ad4744ba
- 출처 데이터셋
- uspto-grants-2015_10
- 특허 번호
- US09163021B2
반응 노트
불러오는 중…