Acetic Anhydride → N-(4-Fluoro-2-methylphenyl)acetamide

HRID 17546

반응식

HRID 17546 반응식
C(O[C:5](=[O:7])[CH3:6])(=O)C.[F:8][C:9]1[CH:15]=[CH:14][C:12]([NH2:13])=[C:11]([CH3:16])[CH:10]=1>C(Cl)(Cl)Cl>[F:8][C:9]1[CH:15]=[CH:14][C:12]([NH:13][C:5](=[O:7])[CH3:6])=[C:11]([CH3:16])[CH:10]=1

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 679824-Fluoro-2-methylaniline

생성물 1

HCID 2737623N-(4-Fluoro-2-methylphenyl)acetamide수율 99.8%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

Acetic anhydride (17.7 ml, 0.19 mol) was dropwise added to 4-fluoro-2-methylaniline (234 g, 0.19 mol). The solidified reaction mixture was dissolved in chloroform, washed with an aqueous saturated sodium hydrogencarbonate solution and saturated brine, then dried over anhydrous sodium sulfate. The solvent was evaporated away under reduced pressure, and the residue was dried with a vacuum pump to obtain the entitled compound (31.7 g, 99%) as a pale red solid.

후처리

  1. customThe solidified reaction mixture
  2. washwashed with an aqueous saturated sodium hydrogencarbonate solution and saturated brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. customThe solvent was evaporated away under reduced pressure
  5. customthe residue was dried with a vacuum pump

출처 및 근거

ORD 기록
ord-b28a3fb55f434213817c419a6f86b40a
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737166B2

연결된 노트

불러오는 중…