Acetic Anhydride → N-(4-Fluoro-2-methylphenyl)acetamide
반응식
C(O[C:5](=[O:7])[CH3:6])(=O)C.[F:8][C:9]1[CH:15]=[CH:14][C:12]([NH2:13])=[C:11]([CH3:16])[CH:10]=1>C(Cl)(Cl)Cl>[F:8][C:9]1[CH:15]=[CH:14][C:12]([NH:13][C:5](=[O:7])[CH3:6])=[C:11]([CH3:16])[CH:10]=1참가 물질
4
실험 절차
Acetic anhydride (17.7 ml, 0.19 mol) was dropwise added to 4-fluoro-2-methylaniline (234 g, 0.19 mol). The solidified reaction mixture was dissolved in chloroform, washed with an aqueous saturated sodium hydrogencarbonate solution and saturated brine, then dried over anhydrous sodium sulfate. The solvent was evaporated away under reduced pressure, and the residue was dried with a vacuum pump to obtain the entitled compound (31.7 g, 99%) as a pale red solid.
후처리
- customThe solidified reaction mixture
- washwashed with an aqueous saturated sodium hydrogencarbonate solution and saturated brine
- dry with materialdried over anhydrous sodium sulfate
- customThe solvent was evaporated away under reduced pressure
- customthe residue was dried with a vacuum pump
출처 및 근거
- ORD 기록
- ord-b28a3fb55f434213817c419a6f86b40a
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07737166B2
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