4-Methylmorpholine → N-[4-(Hydroxymethyl)phenyl]-N-methylacetamide

HRID 1757452노트

반응식

HRID 1757452 반응식
[C:1]([N:4]([C:6]1[CH:14]=[CH:13][C:9]([C:10](O)=[O:11])=[CH:8][CH:7]=1)[CH3:5])(=[O:3])[CH3:2].CN1CCOCC1.ClC(OCC(C)C)=O.[BH4-].[Na+]>O.CN(C=O)C.COCCOC>[C:1]([N:4]([C:6]1[CH:14]=[CH:13][C:9]([CH2:10][OH:11])=[CH:8][CH:7]=1)[CH3:5])(=[O:3])[CH3:2]

참가 물질

8

반응물 4

HCID 79724-MethylmorpholineHCID 62365Isobutyl chloroformateHCID 2834714-(N-methylacetamido)benzoic acidHCID 4311764Sodium borohydride

생성물 1

HCID 54439979N-[4-(Hydroxymethyl)phenyl]-N-methylacetamide

시약·촉매·용매 3

HCID 962Water용매HCID 6228Dimethylformamide용매HCID 80711,2-Dimethoxyethane용매

반응 조건

온도
-20 °C

실험 절차

An oven dried flask, under nitrogen flow, was charged with a stir bar, 4-(N-acetyl-N-methyl-amino)benzoic acid (1.0 g, 5.18 mmol), prepared as in step7, anhydrous DME (10.3 mL), and anhydrous DMF (3.0 mL). The resulting solution was cooled to -20° C., and 4-methylmorpholine (0.60 mL, 5.4 mmol) and isobutyl chloroformate (0.70 mL, 5.4 mmol) were added sequentially via syringe. The reaction mixture was stirred under N2 at -20° C. for 1 hour. The resultant yellow mixture was filtered and the precipitate washed with DME (2×, ~1 mL). The combined filtrate and washings were cooled to 0° C. and sodium borohydride (800 mg, 21.1 mmol) dissolved in water (2.0 mL) was added dropwise. The reaction was stirred at 0° C. for 15 min. and quenched with saturated aqueous ammonium chloride. The resulting mixture was partitionedbetween ethyl acetate and brine. The combined organic layers were dried (MgSO 4), filtered and concentrated in vacuo to give an oil. Purification by flash chromatography on silica gel (90% ethyl acetate/hexane) provided 4-(N-acetyl-N-methyl-amino)benzyl alcohol as a colorless oil which solidified on standing. Recrystallization from hexane provided the alcohol as a colorless solid (543.0 mg, 58.5%). 1H NMR (300 MHz, CDCl3) d 7.45 (2H, d, J=8.5 Hz), 7.18 (2H, d, J=8.5 Hz), 4.75 (2H, s), 3.27 (3H, s), 1.90 (3H, br s). MS m/e 180 (M+H)+, 197 (M+NH4)+.

후처리

  1. customAn oven dried flask
  2. additionunder nitrogen flow, was charged with a stir bar
  3. filtrationThe resultant yellow mixture was filtered
  4. washthe precipitate washed with DME (2×, ~1 mL)
  5. temperatureThe combined filtrate and washings were cooled to 0° C.
  6. additionwas added dropwise
  7. stirringThe reaction was stirred at 0° C. for 15 min.
  8. customquenched with saturated aqueous ammonium chloride
  9. dry with materialThe combined organic layers were dried (MgSO 4)
  10. filtrationfiltered
  11. concentrationconcentrated in vacuo
  12. customto give an oil
  13. customPurification by flash chromatography on silica gel (90% ethyl acetate/hexane)

출처 및 근거

ORD 기록
ord-e14a4690f355456cb6dc38df1d244fbb
출처 데이터셋
uspto-grants-1995_08
특허 번호
US05446062

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