Sodium Hydroxide → 7-[3-[4-(3-Phenylthio-propyl)-1-piperazinyl]-propyl]-theophylline

HRID 1758703

반응식

HRID 1758703 반응식
Cl[CH2:2][CH2:3][CH2:4][N:5]1[C:14]2[C:13](=[O:15])[N:11]([CH3:12])[C:10](=[O:16])[N:9]([CH3:17])[C:8]=2[N:7]=[CH:6]1.[C:18]1([S:24][CH2:25][CH2:26][CH2:27][N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.[OH-].[Na+]>>[C:18]1([S:24][CH2:25][CH2:26][CH2:27][N:28]2[CH2:33][CH2:32][N:31]([CH2:2][CH2:3][CH2:4][N:5]3[C:14]4[C:13](=[O:15])[N:11]([CH3:12])[C:10](=[O:16])[N:9]([CH3:17])[C:8]=4[N:7]=[CH:6]3)[CH2:30][CH2:29]2)[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

참가 물질

4

반응물 3

HCID 14798Sodium HydroxideHCID 760117-(3-Chloropropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dioneHCID 21954921-(3-(Phenylthio)propyl)piperazine

생성물 1

HCID 30617397-[3-[4-(3-Phenylthio-propyl)-1-piperazinyl]-propyl]-theophylline

실험 절차

7-(3-Chloropropyl)-theophylline (1 mole) and 1-(3-phenylthiopropyl)-piperazine are refluxed for 24 hours in a 50% aqueous-alcoholic solution. On completion of the reaction, sodium hydroxide (1 mole) is then added. The mixture is extracted with methylene chloride and washed with water, after which the solvent is evaporated off and the residue is recrystallized from ethanol.

후처리

  1. additionis then added
  2. extractionThe mixture is extracted with methylene chloride
  3. washwashed with water
  4. customafter which the solvent is evaporated off
  5. customthe residue is recrystallized from ethanol

출처 및 근거

ORD 기록
ord-ff943f179a204bf99252551d0e6d29af
출처 데이터셋
uspto-grants-1983_02
특허 번호
US04374835

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