L-Alanyl-L-proline → HCID 13105147, 화합물

HRID 1758834노트

반응식

HRID 1758834 반응식
[Na+].[CH3:2][CH:3]([CH3:9])[C:4](=O)[C:5]([O-:7])=[O:6].[NH2:10][C@H:11]([C:13]([N:15]1[CH2:22][CH2:21][CH2:20][C@H:16]1[C:17]([OH:19])=[O:18])=[O:14])[CH3:12].C([BH3-])#N.[Na+]>>[C:5]([CH:4]([NH:10][C@H:11]([C:13]([N:15]1[CH2:22][CH2:21][CH2:20][C@H:16]1[C:17]([OH:19])=[O:18])=[O:14])[CH3:12])[CH:3]([CH3:9])[CH3:2])([OH:7])=[O:6]

참가 물질

4

반응물 3

HCID 83525L-Alanyl-L-prolineHCID 2724059Sodium 3-methyl-2-oxobutyrateHCID 5003444Sodium cyanoborohydride

생성물 1

HCID 13105147HCID 13105147, 화합물수율 73.2%

실험 절차

A mixture of 3-methyl-2-oxobutyric acid sodium salt (1.46 g) and L-alanyl-L-proline (0.40 g) was treated with sodium cyanoborohydride (0.41 g) as described above. Crude N-(1-carboxy-2-methylpropyl)L-alanyl-L-proline (0.45 g) was obtained by elution from ion-exchange resin. The product melted at 131°-142°. The nmr spectrum shows complex absorption in the 4.6 to 3.3 region, a broad multiplet centered at 2.2 and doublets at 1.65 and 1.1 ppm.

출처 및 근거

ORD 기록
ord-bb02c66d3b694aa4a59613e44d126569
출처 데이터셋
uspto-grants-1983_02
특허 번호
US04374829

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