Hydrochloric Acid → HCID 86738481, 화합물

HRID 1759164노트

반응식

HRID 1759164 반응식
[CH3:1][O:2][C:3]([P:7]([CH3:11])(=[O:10])[O:8]C)([O:5][CH3:6])[CH3:4].Cl.[OH-].[Na+:14]>>[CH3:1][O:2][C:3]([P:7]([CH3:11])(=[O:8])[O-:10])([O:5][CH3:6])[CH3:4].[Na+:14]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 54446102Methyl (1,1-dimethoxyethyl)methylphosphinate

생성물 1

HCID 86738481HCID 86738481, 화합물

실험 절차

The phosphinate ester product of Example 16 (220 g) was refluxed 2 hr with aqueous sodium hydroxide (2 N: 660 ml). The cooled solution was taken to pH 7.0 with conc. hydrochloric acid, evaporated in vacuo and the solid residue was triturated with methanol and insoluble material filtered off. The filtrate was again evaporated to dryness, the residue triturated with methanol and further insoluble material filtered off. The filtrate was finally evaporated to dryness, triturated with acetone and filtered to give the title compound (2.9 g) mp 258°-262° C., identical (ir nmr) with the product from Example 17.

후처리

  1. customevaporated in vacuo
  2. customthe solid residue was triturated with methanol and insoluble material
  3. filtrationfiltered off
  4. customThe filtrate was again evaporated to dryness
  5. customthe residue triturated with methanol and further insoluble material
  6. filtrationfiltered off
  7. customThe filtrate was finally evaporated to dryness
  8. customtriturated with acetone
  9. filtrationfiltered

출처 및 근거

ORD 기록
ord-9cf1218397fa40f99dfc1368acc821ef
출처 데이터셋
uspto-grants-1982_07
특허 번호
US04339443

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