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Phenol → alpha-Hydroxy-beta-Phenoxy-N-(1-Methylethyl)-3-Methoxybenzenepropanamide

HRID 1759531
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인쇄 미리보기

반응식

HRID 1759531 반응식
[CH3:1][CH:2]([NH:4][C:5]([CH:7]1[CH:9]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([O:16][CH3:17])[CH:11]=2)[O:8]1)=[O:6])[CH3:3].[C:18]1(O)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.[H-].[Na+].C1OCCOCCOCCOCCOCC[O:29]C1>C(#N)C>[OH:29][CH:7]([CH:9]([O:8][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([O:16][CH3:17])[CH:11]=1)[C:5]([NH:4][CH:2]([CH3:1])[CH3:3])=[O:6]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 996PhenolHCID 24758Sodium hydrideHCID 2855718-Crown-6HCID 20490547N-(1-methylethyl)-3-(3-methoxyphenyl)-2-oxiranecarboxamide

생성물 1

HCID 20490544alpha-Hydroxy-beta-Phenoxy-N-(1-Methylethyl)-3-Methoxybenzenepropanamide

시약·촉매·용매 1

HCID 6342Acetonitrile
용매

실험 절차

This compound was prepared from N-(1-methylethyl)-3-(3-methoxyphenyl)-2-oxiranecarboxamide (14.3 g.), phenol (6.0 g.), sodium hydride (50% oil dispersion, 3.2 g.), 18-crown-6 (1.8 g.), and acetonitrile (500 ml.) as described in Example 12. The compound obtained as an oil was used directly in the subsequent reaction.

후처리

  1. customThe compound obtained as an oil
  2. customwas used directly in the subsequent reaction

출처 및 근거

ORD 기록
ord-6a92c2e13c7f4dec8fa36a2ca0a72581
출처 데이터셋
uspto-grants-1982_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04341718

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