O-Cresol → 1-(2-Bromoethoxy)-2-methylbenzene

HRID 1760923노트

반응식

HRID 1760923 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].[CH2:9](Br)[CH2:10][Br:11].[OH-].[Na+]>>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH2:9][CH2:10][Br:11]

참가 물질

4

반응물 3

HCID 335O-CresolHCID 78391,2-DibromoethaneHCID 14798Sodium Hydroxide

생성물 1

HCID 16225721-(2-Bromoethoxy)-2-methylbenzene

반응 조건

온도
100 °C

실험 절차

22.4 ml (0.2 mole) of 2-methyiphenol and 34.6 ml (0.4 mole) of ethylene dibromide are mixed and heated at 100° C. The mixture is stirred vigourously with 125 ml 1.6N NaOH, continued heat and stirred till the pH value to 7. Upon cooling, after filtrating the extracted solids, the mixed solution's organic layer is extracted with chloroform and rinsing the extracted solids with NaCl and MgSO4. The generated product is filled into silica gel chromatography columns. The mixture solution of Hexane and Ethylacetate was used as the eluent solution. Upon purification, until white crystallization 2-methyphenoxy)ethylbromide are obtained.

후처리

  1. temperaturecontinued heat
  2. temperatureUpon cooling
  3. filtrationafter filtrating the extracted solids
  4. extractionthe mixed solution's organic layer is extracted with chloroform
  5. washrinsing the extracted solids with NaCl and MgSO4
  6. additionThe generated product is filled into silica gel chromatography columns
  7. customUpon purification
  8. customuntil white crystallization 2-methyphenoxy)ethylbromide
  9. customare obtained

출처 및 근거

ORD 기록
ord-dbbb47d58145482195284819d2bcb31d
출처 데이터셋
uspto-grants-2005_01
특허 번호
US06846826B2

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