Hydroxide → 4-Hydroxy-4'-methoxybiphenyl

HRID 1761658노트

반응식

HRID 1761658 반응식
C([C:4]1[C:5]([OH:17])=[CH:6][C:7]2C[CH2:9][CH2:10][CH:11]([CH2:14][CH2:15][CH3:16])[C:12]=2[CH:13]=1)(=O)C.[OH-].S(OC)([O:22][CH3:23])(=O)=O>>[CH3:23][O:22][C:16]1[CH:9]=[CH:10][C:11]([C:12]2[CH:13]=[CH:4][C:5]([OH:17])=[CH:6][CH:7]=2)=[CH:14][CH:15]=1

참가 물질

4

반응물 3

HCID 961HydroxideHCID 6497Dimethyl SulfateHCID 212421503-Acetyl-5-propyl-5,6,7,8-tetrahydro-2-naphthol

생성물 1

HCID 110308394-Hydroxy-4'-methoxybiphenyl

실험 절차

4,4'-Dihydroxydiphenyl (1) (32 g 0.17 mol) was dissolved in 2M solution hydroxide solution (0.34 mol) and dimethyl sulphate (22 g 0.175 mol) was added slowly with stirring over half an hour. The sodium salt of the required product was filtered off and dried. The yield was 24 g. The sodium salt of the phenol (24 g) was treated with acetyl chloride (150 cm3), filtered and excess acetyl chloride removed. Work up gave 4- methoxy-4'-acetoxydiphenyl (4) (22 g).

후처리

  1. additionwas added slowly
  2. filtrationThe sodium salt of the required product was filtered off
  3. customdried
  4. additionThe sodium salt of the phenol (24 g) was treated with acetyl chloride (150 cm3)
  5. filtrationfiltered
  6. customexcess acetyl chloride removed

출처 및 근거

ORD 기록
ord-712fec2504a749cfa2b8a87ad88f1ffa
출처 데이터셋
uspto-grants-1989_05
특허 번호
US04826977

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