Hydrochloric Acid → HCID 10997097, 화합물
반응식
[CH2:1]([N:4]([C:9]([O:11]C)=O)[C:5](=O)[CH2:6][NH2:7])[C:2]#[CH:3].[OH-:13].[Na+].Cl>CO>[CH2:1]([N:4]1[CH2:5][C:6](=[O:13])[NH:7][C:9]1=[O:11])[C:2]#[CH:3]참가 물질
5
반응 조건
- 온도
- 70 °C
실험 절차
2.0 g of N-propargyl-N-methoxycarbonylglycinamide were added to the mixture of 5 ml of methanol and 2.5 ml of 20% aqueous solution of sodium hydroxide and maintained at 70° C. for an hour. After cooled down to room temperature; the reaction mixture was neutralized with concentrated hydrochloric acid followed by concentrating and drying the same by an evaporation under reduced pressure. Then it was extracted with acetonitrile and sodium chloride was removed off from the extract by filtration. The solvent was evaporated off from the filtrate to obtain 1.4 g of 1-propargyl-2,4-dioxoimidazolidine (melting point: 124°-125° C.).
후처리
- temperatureAfter cooled down to room temperature
- concentrationby concentrating
- customdrying the
- customsame by an evaporation under reduced pressure
- extractionThen it was extracted with acetonitrile and sodium chloride
- customwas removed off from the
- extractionextract by filtration
- customThe solvent was evaporated off from the filtrate
출처 및 근거
- ORD 기록
- ord-f05c517ad5bc4a8baf1a6ee67ce0ad6f
- 출처 데이터셋
- uspto-grants-1989_05
- 특허 번호
- US04827020
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