Hydrochloric Acid → 2-(4-Dimethylaminophenyl)benzofuran-7-carboxylic acid

HRID 1761911노트

반응식

HRID 1761911 반응식
[CH3:1][N:2]([CH3:22])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:11]3[C:17]([C:18]([O:20]C)=[O:19])=[CH:16][CH:15]=[CH:14][C:12]=3[CH:13]=2)=[CH:5][CH:4]=1.[OH-].[Na+].Cl>CO.O1CCCC1>[CH3:1][N:2]([CH3:22])[C:3]1[CH:4]=[CH:5][C:6]([C:9]2[O:10][C:11]3[C:17]([C:18]([OH:20])=[O:19])=[CH:16][CH:15]=[CH:14][C:12]=3[CH:13]=2)=[CH:7][CH:8]=1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 14229715Methyl 2-(4-dimethylaminophenyl)benzofuran-7-carboxylate

생성물 1

HCID 142297162-(4-Dimethylaminophenyl)benzofuran-7-carboxylic acid수율 99.3%

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

반응 조건

온도
50 °C

실험 절차

920 mg of methyl 2-(4-dimethylaminophenyl)benzofuran-7-carboxylate are dissolved in a mixture of 20 ml of methanol and 20 ml of tetrahydrofuran. 10 ml of an aqueous 1N sodium hydroxide solution are added to the solution and the mixture is heated at 50° C. for 40 minutes. After cooling, the reaction mixture is neutralized with 10% hydrocloric acid and extracted with ethyl acetate. The extract is dried and evaporated to remove solvent to give 870 mg of 2-(4-dimethylaminophenyl)benzofuran-7-carboxylic acid as yellow powder.

후처리

  1. temperatureAfter cooling
  2. extractionextracted with ethyl acetate
  3. customThe extract is dried
  4. customevaporated
  5. customto remove solvent

출처 및 근거

ORD 기록
ord-89298c6253404621aebc81862be82b30
출처 데이터셋
uspto-grants-1989_05
특허 번호
US04829067

반응 노트

불러오는 중…