Acetyl chloride → Methyl 3-acetyl-2-methylbenzofuran-7-carboxylate

HRID 1761934노트

반응식

HRID 1761934 반응식
[CH3:1][C:2]1[O:3][C:4]2[C:10]([C:11]([O:13][CH3:14])=[O:12])=[CH:9][CH:8]=[CH:7][C:5]=2[CH:6]=1.[C:15](Cl)(=[O:17])[CH3:16].[Cl-].[Al+3].[Cl-].[Cl-]>ClC(Cl)C>[C:15]([C:6]1[C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([C:11]([O:13][CH3:14])=[O:12])[C:4]=2[O:3][C:2]=1[CH3:1])(=[O:17])[CH3:16]

참가 물질

5

반응물 3

HCID 6367Acetyl chlorideHCID 6451240Aluminum(III) ChlorideHCID 14229729Methyl 2-methyl-1-benzofuran-7-carboxylate

생성물 1

HCID 14229733Methyl 3-acetyl-2-methylbenzofuran-7-carboxylate수율 88.5%

시약·촉매·용매 1

HCID 63651,1-Dichloroethane용매

실험 절차

A mixture of 1.0 g of methyl 2-methylbenzofuran-7-carboxylate, 1.24 g of acetyl chloride, 2.15 g of aluminum chloride and 20 ml of dichloroethane is heated at 50°-60° C. for 1 hour. The reaction mixture is poured into ice-water and the aqueous mixture is extracted with chloroform. The extract is washed with water, dried and evaporated to remove solvent. The residue is recrystallized from ethyl acetate-n-hexane to give 1.08 g of methyl 3-acetyl-2-methylbenzofuran-7-carboxylate as colorless needles.

후처리

  1. temperatureis heated at 50°-60° C. for 1 hour
  2. extractionthe aqueous mixture is extracted with chloroform
  3. washThe extract is washed with water
  4. customdried
  5. customevaporated
  6. customto remove solvent
  7. customThe residue is recrystallized from ethyl acetate-n-hexane

출처 및 근거

ORD 기록
ord-f6323838053e448f9fcde35dcc226a4c
출처 데이터셋
uspto-grants-1989_05
특허 번호
US04829067

반응 노트

불러오는 중…