Hydrochloric Acid → 3-(1H-pyrazol-4-yl)propan-1-amine dihydrochloride

HRID 1763215노트

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HRID 1763215 반응식
C1(=O)[NH:5]C(=O)C2=CC=CC=C12.[ClH:12].C1N=C(N)C2N=CN([C@@H]3O[C@H](COP(OP(OC[C@H]4O[C@@H]([N:43]5[CH:48]=[C:47]([C:49]([NH2:51])=O)[CH2:46][CH:45]=[CH:44]5)[C@H](O)[C@@H]4O)(O)=O)(O)=O)[C@@H](O)[C@H]3O)C=2N=1>>[ClH:12].[ClH:12].[NH2:5][CH2:44][CH2:45][CH2:46][C:47]1[CH:48]=[N:43][NH:51][CH:49]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 6809PhthalimideHCID 439153Nadh

생성물 1

HCID 227549333-(1H-pyrazol-4-yl)propan-1-amine dihydrochloride

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온도
4 °C

실험 절차

This phthalimide intermediate (8.0 l gram, 0.03 mole) was refluxed in 100 ml. of 6 normal hydrochloric acid overnight. The clear solution was cooled to 4° C., phthalic acid removed by filtration, and the filtrate evaporated to dryness to give a product which, after recrystallization from a mixture of ethanol and ethyl ether, amounted to 4.4 grams of a white solid identified as 4-(3-aminopropyl)-pyrazole dihydrochloride, melting point 189°-190° C. This pyrazole compound could be coupled to the activated dextran by reaction of the terminal amino group, but the resulting affinity resin, in which the coupling arm had a length of only 6 Angstrom units, had poor binding capacity for the binary complex of alcohol dehydrogenase and NAD.

후처리

  1. customphthalic acid removed by filtration
  2. customthe filtrate evaporated to dryness
  3. customto give a product which
  4. customafter recrystallization
  5. additionfrom a mixture of ethanol and ethyl ether
  6. customThis pyrazole compound could be coupled to the activated dextran by reaction of the terminal amino group

출처 및 근거

ORD 기록
ord-49459690fdce43d992059cac21931e74
출처 데이터셋
uspto-grants-1978_09
특허 번호
US04111751

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