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Hydrochloric Acid → HCID 15871116, 화합물

HRID 1764972
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HRID 1764972 반응식
[BH4-].[Na+].[C:3]([C@:5]12[CH2:29][C:28](=[O:30])[CH2:27][CH2:26][C@:25]1([CH3:31])[C:24]1[CH2:23][CH2:22][C@@:21]3([CH3:32])[C@@H:9]([CH2:10][CH2:11][C@@H:12]3[C@H:13]([CH3:20])[CH2:14][CH2:15][CH2:16][CH:17]([CH3:19])[CH3:18])[C:8]=1[CH2:7][CH2:6]2)#[N:4].Cl>C(O)C>[C:3]([C@:5]12[CH2:29][C@@H:28]([OH:30])[CH2:27][CH2:26][C@:25]1([CH3:31])[C:24]1[CH2:23][CH2:22][C@@:21]3([CH3:32])[C@@H:9]([CH2:10][CH2:11][C@@H:12]3[C@H:13]([CH3:20])[CH2:14][CH2:15][CH2:16][CH:17]([CH3:19])[CH3:18])[C:8]=1[CH2:7][CH2:6]2)#[N:4].[C:3]([C@:5]12[CH2:29][C@H:28]([OH:30])[CH2:27][CH2:26][C@:25]1([CH3:31])[C:24]1[CH2:23][CH2:22][C@@:21]3([CH3:32])[C@@H:9]([CH2:10][CH2:11][C@@H:12]3[C@H:13]([CH3:20])[CH2:14][CH2:15][CH2:16][CH:17]([CH3:19])[CH3:18])[C:8]=1[CH2:7][CH2:6]2)#[N:4]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 15871126HCID 15871126, 화합물

생성물 2

HCID 15871116HCID 15871116, 화합물HCID 15871117HCID 15871117, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

327 mg sodium borohydride are added to a solution of 1.76 g 5-cyano-5α-cholest-8-en-3-one in 200 ml ethanol at room temperature. The reaction mixture is stirred for 4 hours. After addition of hydrochloric acid (1 N) the resulting mixture is extracted with dichloromethane. The organic layer is separated, dried over anhydrous sodium sulphate and filtered. After evaporation of the solvent the residue is chromatographed with a mixture of hexane and ethyl acetate to give 0.36 mg 5-cyano-5α-cholest-8-en-3β-ol and 1.00 g 5-cyano-5α-cholest-8-en-3α-ol as white solids.

후처리

  1. extractionis extracted with dichloromethane
  2. customThe organic layer is separated
  3. dry with materialdried over anhydrous sodium sulphate
  4. filtrationfiltered
  5. customAfter evaporation of the solvent the residue
  6. customis chromatographed with a mixture of hexane and ethyl acetate

출처 및 근거

ORD 기록
ord-5bc6ee5123e742a28c0b16b195d0f9da
출처 데이터셋
uspto-grants-2007_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
USRE039678E1

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