Hydrochloric Acid → HCID 23031104, 화합물

HRID 1766647노트

반응식

HRID 1766647 반응식
C[O:2][C:3]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[C:20]([CH3:21])=[CH:19][C:18]([N+:22]([O-:24])=[O:23])=[C:17]3[C:13]=2[CH2:14][CH2:15][CH2:16]3)=[CH:7][C:4]=1[CH:5]=[O:6].B(Cl)(Cl)Cl.CO.Cl>ClCCl>[OH:2][C:3]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[C:20]([CH3:21])=[CH:19][C:18]([N+:22]([O-:24])=[O:23])=[C:17]3[C:13]=2[CH2:14][CH2:15][CH2:16]3)=[CH:7][C:4]=1[CH:5]=[O:6]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 25135Boron TrichlorideHCID 230312052-Methoxy-5-(5-methyl-7-nitroindan-4-yloxy)benzaldehyde

생성물 1

HCID 23031104HCID 23031104, 화합물수율 74.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

2-Methoxy-5-(5-methyl-7-nitroindan-4-yloxy) benzaldehyde (2.03 g) was dissolved in dichloromethane (80 mL). To the solution was added dropwise a 1 mol/L solution of boron trichloride in dichloromethane (20 mL) under ice-cooling with stirring. The reaction mixture was stirred at room temperature for 24 hours. To the reaction mixture was added dropwise methanol (10 mL) under ice-cooling with stirring. After adding diluted hydrochloric acid, the reaction mixture was extracted with ethyl acetate. The organic layer was washed with brine, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give the title compound (1.45 g).

후처리

  1. temperaturecooling
  2. stirringThe reaction mixture was stirred at room temperature for 24 hours
  3. temperaturecooling
  4. stirringwith stirring
  5. extractionthe reaction mixture was extracted with ethyl acetate
  6. washThe organic layer was washed with brine
  7. dry with materialdried over anhydrous magnesium sulfate
  8. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-673dbc83f4e7472797f5dce0eda61ea6
출처 데이터셋
uspto-grants-2007_06
특허 번호
US07230031B2

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