Hydrochloric Acid → [4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-acetic acid

HRID 1767881노트

반응식

HRID 1767881 반응식
[CH3:1][C:2]1[N:3]=[C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=2)[S:5][C:6]=1[CH2:7][C:8]#N.[OH-:20].[Na+].[OH2:22].Cl>C(O)C>[CH3:1][C:2]1[N:3]=[C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=2)[S:5][C:6]=1[CH2:7][C:8]([OH:22])=[O:20]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 23614503[4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-acetonitrile

생성물 1

HCID 17972178[4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-acetic acid

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
100 °C

실험 절차

A mixture of [4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-acetonitrile (8.86 g, 31 mmol), sodium hydroxide (12.5 g, 314 mmol), water (160 ml) and ethanol (160 ml) was stirred vigorously at 100° C. for 2.5 h. The reaction mixture was poured onto crushed ice and aqueous HCl and extracted three times with dichloromethane. The combined extracts were washed with water and brine, and dried over anhydrous sodium sulfate. Evaporation of the solvent under reduced pressure gave 9.5 g (quant.) of the title compound as light yellow solid.

후처리

  1. additionThe reaction mixture was poured
  2. extractionextracted three times with dichloromethane
  3. washThe combined extracts were washed with water and brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. customEvaporation of the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-bb43e20114094220b1245dd341010c87
출처 데이터셋
uspto-grants-2007_06
특허 번호
US07235572B2

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