Cyclohexylamine → N-cyclohexyl-2-phenylprop-2-enamide

HRID 1769620

반응식

[C:1]([OH:11])(=O)[C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=[CH2:3].CN1CCOCC1.ClC(OCC(C)C)=O.[CH:27]1([NH2:33])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1>>[CH:27]1([NH:33][C:1](=[O:11])[C:2]([C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=2)=[CH2:3])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1

참가 물질

반응물 4

HCID 7965Cyclohexylamine

HCID 79724-Methylmorpholine

HCID 62365Isobutyl chloroformate

HCID 68114Atropic acid

생성물 1

HCID 343735N-cyclohexyl-2-phenylprop-2-enamide수율 28.9%

실험 절차

This compound was made from atropic acid (10.48 g, 70.8 mmol), N-methylmorpholine (7.8 ml, 70.9 mmol), iso-butyl chloroformate (9.2 ml, 70.9 mmol), and cyclohexylamine (8.1 ml, 70.7 mmol) using the procedure described in Example 3. The crude product was purified by recrystallisation from cyclohexane to give the product (4.69 g), as white crystals, m.p. 131°-133°. (Found: C, 78.7; H, 8.8; N, 5.95. C15H19NO requires C, 78.6; H, 8.35; N, 6.1%.)

후처리

customThe crude product was purified by recrystallisation from cyclohexane

출처 및 근거

ORD 기록: ord-80e17721ba31412aa57fade695b834bd
출처 데이터셋: uspto-grants-1995_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05382583

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