Hydrochloric Acid → 5-Bromo-2-methoxy-3-methylbenzoic acid

HRID 1771694노트

반응식

HRID 1771694 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH3:14])[C:5]([O:12][CH3:13])=[C:6]([CH:11]=1)[C:7]([O:9]C)=[O:8].[OH-].[Na+].O.Cl>C1COCC1>[Br:1][C:2]1[CH:3]=[C:4]([CH3:14])[C:5]([O:12][CH3:13])=[C:6]([CH:11]=1)[C:7]([OH:9])=[O:8]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 2764346Methyl 5-bromo-2-methoxy-3-methylbenzoate

생성물 1

HCID 9619195-Bromo-2-methoxy-3-methylbenzoic acid수율 73.4%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of methyl 5-bromo-2-methoxy-3-methyl-benzoate (2.6 g, 10.0 mmol, 1.0 eq) in THF (20 mL) was added an aqueous solution of NaOH (2M, 20 mL, 40 mmol, 4.0 eq). The mixture was stirred at room temperature for 5 h. Water was added and the aqueous layer was acidified to pH 9 by addition of 1M HCl. The THF was removed in vacuo and the aqueous layer was further acidified to pH 4-5 with 1M HCl. The solid that precipitated from the reaction was collected by filtration and dried to give the title compound as a white solid (1.8 g, 73%).

후처리

  1. customThe THF was removed in vacuo
  2. customThe solid that precipitated from the reaction
  3. filtrationwas collected by filtration
  4. customdried

출처 및 근거

ORD 기록
ord-c47194d446964f7cb9ee6b669610bc9f
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09249085B2

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