Hydrochloric Acid → 3-Bromo-4-(trifluoromethoxy)benzoic acid

HRID 1773952노트

반응식

HRID 1773952 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][C:11]([F:14])([F:13])[F:12])[CH:5]=[O:6].[OH:15]O.Cl>CO.[OH-].[Na+]>[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][C:11]([F:12])([F:13])[F:14])[C:5]([OH:15])=[O:6]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 784Hydrogen PeroxideHCID 131504163-Bromo-4-(trifluoromethoxy)benzaldehyde

생성물 1

HCID 202740913-Bromo-4-(trifluoromethoxy)benzoic acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 14798Sodium Hydroxide용매

반응 조건

온도
0 °C

실험 절차

To an ice-cooled solution of 3-bromo-4-(trifluoromethoxy)benzaldehyde (3.00 g, 11.2 mmol, 1 eq.) in MeOH (14 mL), a solution of hydrogen peroxide (30% wt solution in water, 14 mL, 11.2 mmol, 1 eq.) in 15% aq. NaOH soln. (14 mL) was added dropwise. The reaction mixture was stirred at 0° C. for 1 hour and further at r.t. for 18 hours. The reaction mixture was acidified by addition of conc. HCl. The suspension was filtered off and the filter cake was rinsed with H2O. The resulting white solid was dried under h.v. to give the title compound. The product was used without further purification.

후처리

  1. addition(14 mL) was added dropwise
  2. filtrationThe suspension was filtered off
  3. washthe filter cake was rinsed with H2O
  4. customThe resulting white solid was dried under h.v

출처 및 근거

ORD 기록
ord-2f3609b69d7549179c6830933b59da0a
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09255090B2

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