Acetone → ST001233

반응식

[CH:1](=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:9][C:10]([CH3:12])=O.[C:13](#[N:17])[CH2:14][C:15]#[N:16].C([O-])(=O)C.[NH4+:22]>>[NH2:16][C:15]1[N:22]=[C:10]([CH3:12])[CH:9]=[C:1]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[C:14]=1[C:13]#[N:17]

참가 물질

반응물 4

HCID 180Acetone

HCID 240Benzaldehyde

HCID 8010Malononitrile

HCID 517165Ammonium Acetate

생성물 1

HCID 610514ST001233수율 40%

실험 절차

Benzaldehyde (406 μl, 4 mmol), acetone (294 μl, 4 mmol), malononitrile (264 mg, 4 mmol) e ammonium acetate (462 mg, 6 mmol) were placed in a microwave tube and irradiated with microwaves (Solvent: none; Power: 150 W; Ramp time: 5 min; Heating time: 10 min; Temperature: 100° C.; Pressure: 175 psi; Stirring: on; Cooling: on). At the end of the microwave irradiation cycle, the solvent was removed under reduced pressure. The crude product was purified by flash chromatography on silica gel (petroleum ether/ethyl acetate=90/10) to obtain 2-amino-4-phenyl-6-methylnicotinonitrile in 40% yield.