Hydrochloric Acid → HCID 15882750, 화합물
반응식
Br[CH2:2][C:3]1[C:4]([O:6][C:7](=[O:10])[C:8]=1[CH3:9])=[O:5].[OH-:11].[Na+].Cl.[Cl-].[Na+]>CCCCCC.C(OCC)(=O)C>[OH:11][CH2:2][C:3]1[C:4]([O:6][C:7](=[O:10])[C:8]=1[CH3:9])=[O:5]참가 물질
6
실험 절차
To 2-bromomethyl-3-methylmaleic anhydride (1.25 g, 6.10 mmol) was added 5 M aqueous sodium hydroxide solution (4 mL) at room temperature, and the mixture was stirred for 12 h. The reaction mixture was adjusted to pH 1 with 5 M hydrochloric acid (5 mL), added with sodium chloride and extracted three times with ethyl acetate. The combined organic layer was concentrated under reduced pressure, and the residue thus obtained was subjected to silica gel column chromatography (hexane-ethyl acetate 2:1) to give 227 mg of the title compound as oil (yield: 26%).
후처리
- extractionextracted three times with ethyl acetate
- concentrationThe combined organic layer was concentrated under reduced pressure
- customthe residue thus obtained
출처 및 근거
- ORD 기록
- ord-251fecc967e14b808c91fed8ac5663f3
- 출처 데이터셋
- uspto-grants-2016_02
- 특허 번호
- US09260375B2
반응 노트
불러오는 중…