Ethyl formate → Ethyl 2-(benzyloxy)-3-oxopropanoate

HRID 1774432

반응식

HRID 1774432 반응식
[H-].[Na+].[CH:3]([O:5][CH2:6][CH3:7])=[O:4].C([O:10][C:11](=O)[CH2:12][O:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)C>CCOCC>[CH2:14]([O:13][CH:12]([CH:11]=[O:10])[C:3]([O:5][CH2:6][CH3:7])=[O:4])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

참가 물질

5

반응물 3

HCID 8025Ethyl formateHCID 24758Sodium hydrideHCID 290299Ethyl 2-(benzyloxy)acetate

생성물 1

HCID 19903223Ethyl 2-(benzyloxy)-3-oxopropanoate

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To a suspension of sodium hydride (3.3 g, 60% in paraffin oil, 82.5 mmol) in dry ether (100 mL) and dry ethyl formate (5.55 g, 75 mmol) was added ethyl(benzyloxy)acetate (14.57 g, 75 mmol) dropwise with stirring. The resulting mixture solution was then refluxed for 2 h and concentrated to give crude ethyl 2-(benzyloxy)-3-oxopropanoate which was used in the subsequent step without further purification.

후처리

  1. temperatureThe resulting mixture solution was then refluxed for 2 h
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-20ac485fa36648d1ac8954084203c358
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09260413B2

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