Sodium Hydroxide → 3-(4-(Methylthio)phenylamino)-3-oxopropanoic acid

HRID 1776492노트

반응식

HRID 1776492 반응식
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:22])[CH2:11][C:12]([O:14]CC2C=CC=CC=2)=[O:13])=[CH:5][CH:4]=1.[OH-].[Na+]>CO.Cl>[CH3:1][S:2][C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10](=[O:22])[CH2:11][C:12]([OH:14])=[O:13])=[CH:7][CH:8]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 86679443Benzyl 3-(4-(methylthio)phenylamino)-3-oxopropanoate

생성물 1

HCID 622307273-(4-(Methylthio)phenylamino)-3-oxopropanoic acid수율 84%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 887Methanol용매

반응 조건

온도
40 °C

실험 절차

Benzyl 3-(4-(methylthio)phenylamino)-3-oxopropanoate (150 mg, 0.476 mmol) was dissolved in MeOH (1.5 ml). NaOH 1M (500 μl) was added, and the reaction was stirred at 40° C. for 2 hours to achieve completion. The reaction mixture was diluted with HCl 1N and extracted with EtOAc. The organic phase was washed with HCl 1N and brine, dried over Na2SO4 and concentrated under vacuum to give 3-(4-(methylthio)phenylamino)-3-oxopropanoic acid (90 mg, 84% yield).

후처리

  1. extractionextracted with EtOAc
  2. washThe organic phase was washed with HCl 1N and brine
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-dd585cbeb5314c6481e7a600d75e718f
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09265768B2

반응 노트

불러오는 중…