Sodium Hydroxide → 4-Chloro-2-(1H-pyrazol-3-yl)phenol
반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:13])=[C:6](/[CH:8]=[C:9](\C)/[CH:10]=O)[CH:7]=1.CC1C=CC(S([NH:24][NH2:25])(=O)=O)=CC=1.[OH-].[Na+]>C(#N)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:13])=[C:6]([C:8]2[CH:9]=[CH:10][NH:25][N:24]=2)[CH:7]=1참가 물질
5
실험 절차
A mixture of (E)-3-(5-chloro-2-hydroxyphenyl)-2-methylacrylaldehyde (40 mg, 0.203 mmol) and 4-methylbenzenesulfonohydrazide (41.7 mg, 0.224 mmol) in Acetonitrile (3 mL) were stirred at room temperature for 3 h and then acetonitrile (2 mL), Sodiumhydroxide (8.95 mg, 0.224 mmol) were added and the mixture was heated at reflux for 16 h. Product was used for further reaction without purification.
후처리
- temperaturethe mixture was heated
- temperatureat reflux for 16 h
- customProduct was used for further reaction without purification
출처 및 근거
- ORD 기록
- ord-e93c3bc0b808426aa4568fbd3d4bdadd
- 출처 데이터셋
- uspto-grants-2016_02
- 특허 번호
- US09266838B2
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