Benzyl Alcohol → HCID 52463841, 화합물

HRID 1777752

반응식

HRID 1777752 반응식
[CH3:1][C:2]1[CH:6]=[C:5]([CH3:7])[N:4]([CH2:8][C:9]([OH:11])=[O:10])[N:3]=1.[CH2:12](O)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C1CCC(N=C=NC2CCCCC2)CC1>CN(C1C=CN=CC=1)C.CC#N>[CH3:1][C:2]1[CH:6]=[C:5]([CH3:7])[N:4]([CH2:8][C:9]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:10])[N:3]=1

참가 물질

6

반응물 3

HCID 244Benzyl AlcoholHCID 10868DicyclohexylcarbodiimideHCID 572875(3,5-Dimethyl-1H-pyrazol-1-yl)acetic acid

생성물 1

HCID 52463841HCID 52463841, 화합물

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 6342Acetonitrile용매

실험 절차

A mixture of (3,5-dimethyl-1H-pyrazol-1-yl)acetic acid (600 mg), benzyl alcohol (0.402 mL), DMAP (194 mg) and DCC (802 mg) in MeCN (40 mL) was stirred at RT overnight. The suspension was filtered off and the resulting solution was evaporated to dryness. The residue was purified by CC (Hept/EA 7/3) to afford benzyl 2-(3,5-dimethyl-1H-pyrazol-1-yl)acetate (460 mg, white solid). LC-MS (B): tR=0.80 min; [M+H]+: 245.18.

후처리

  1. filtrationThe suspension was filtered off
  2. customthe resulting solution was evaporated to dryness
  3. customThe residue was purified by CC (Hept/EA 7/3)

출처 및 근거

ORD 기록
ord-bd5d153c9de04fad9880e8f06258083d
출처 데이터셋
uspto-grants-2016_02
특허 번호
US09266876B2

연결된 노트

불러오는 중…