Hydrochloric Acid → 3-Phenyloxolan-2-one

HRID 1780212노트

반응식

HRID 1780212 반응식
[C:1]1([C:7]([CH2:18][CH2:19][O:20][C:21](=[O:23])C)(C(OCC)=O)C(OCC)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+].Cl>CO>[C:1]1([CH:7]2[CH2:18][CH2:19][O:20][C:21]2=[O:23])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 19050130Diethyl alpha-phenyl-alpha-(2-acetoxyethyl)malonate

생성물 1

HCID 232693-Phenyloxolan-2-one수율 89.3%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The product of Example 2 (837 g, 2.6M) methanol (1.5 l) and 40% aq. NaOH (1 l, 10M) were heated to reflux for 2 hours. The reaction was then cooled to room temperature and acidified with conc. HCl (1l). The reaction was left as room temperature overnight and then extracted with methyl tert.butyl ether (1 l,500 ml). The extracts were washed with aq. Na2CO3, dried and evaporated to give the title compound(376 g, 89%).

후처리

  1. temperatureto reflux for 2 hours
  2. extractionextracted with methyl tert.butyl ether (1 l,500 ml)
  3. washThe extracts were washed with aq. Na2CO3
  4. customdried
  5. customevaporated

출처 및 근거

ORD 기록
ord-7d238d5a0dac4316a959a22dd1e8cc7f
출처 데이터셋
uspto-grants-1997_05
특허 번호
US05629432

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