Carbon tetrabromide → HCID 57589154, 화합물

HRID 1782764노트

반응식

HRID 1782764 반응식
[C:1]1([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:6]=[CH:5][C:4]([CH2:7][O:8][C:9]2[CH:18]=[CH:17][C:12]([O:13][CH2:14][CH2:15]O)=[CH:11][CH:10]=2)=[CH:3][CH:2]=1.[Br:25]C(Br)(Br)Br.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>ClCCl>[Br:25][CH2:15][CH2:14][O:13][C:12]1[CH:17]=[CH:18][C:9]([O:8][CH2:7][C:4]2[CH:5]=[CH:6][C:1]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[CH:2][CH:3]=2)=[CH:10][CH:11]=1

참가 물질

5

반응물 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 575890602-[4-(Biphenyl-4-ylmethoxy)phenoxy]ethanol

생성물 1

HCID 57589154HCID 57589154, 화합물수율 50.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

800 mg of 2-[4-(biphenyl-4-ylmethoxy)phenoxy]ethanol are introduced into 25 ml of dichloromethane under argon, 1.16 g of tetrabromomethane are added, and the mixture is stirred at room temperture for 10 minutes. The mixture is cooled to 0° C. and, after addition of 1.83 g of triphenylphosphine, stirred at 0° C. for one hour and at room temperature for 2 hours. It is concentrated, and the residue is taken up in a little dichloromethane and filtered through silica gel. 480 mg of product are obtained.

후처리

  1. stirringstirred at 0° C. for one hour and at room temperature for 2 hours
  2. concentrationIt is concentrated
  3. filtrationfiltered through silica gel

출처 및 근거

ORD 기록
ord-a1467a0cad4b4895b545d78df6710d60
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07498460B2

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