Hydrochloric Acid → (2R)-2-hydroxy-2-(2-methoxyphenyl)acetic acid
반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C@@H:9]([OH:14])[C:10]([O:12]C)=[O:11].[OH-].[Na+].Cl>CO>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C@@H:9]([OH:14])[C:10]([OH:12])=[O:11]참가 물질
5
실험 절차
To a solution of 19 g of methyl (2R)-2-(methoxyphenyl)-2-hydroxyethanoate (cf. Journal of Chemical Society, Parkintrans 1, 2253-2255 (1992)) in 50 ml of methanol, 50 ml of 3N aqueous sodium hydroxide solution was added, followed by 12 hours' stirring at room temperature. Distilling the methanol off under reduced pressure, the reaction liquid was acidified with 1N hydrochloric acid and extracted with chloroform. The organic layer was dried over anhydrous sodium sulfate and the solvent was distilled off under reduced pressure, to provide 11 g of the title compound.
후처리
- distillationDistilling the methanol off under reduced pressure
- customthe reaction liquid
- extractionextracted with chloroform
- dry with materialThe organic layer was dried over anhydrous sodium sulfate
- distillationthe solvent was distilled off under reduced pressure
출처 및 근거
- ORD 기록
- ord-debd0f3dfe2643b0a287161a47507876
- 출처 데이터셋
- uspto-grants-2009_03
- 특허 번호
- US07504432B2
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