Hydrazine hydrate (1:1) → 2-(5-Methylisoxazol-3-yl)acetohydrazide
반응식
C[O:2][C:3](=O)[CH2:4][C:5]1[CH:9]=[C:8]([CH3:10])[O:7][N:6]=1.O.[NH2:13][NH2:14]>C(O)CCC>[CH3:10][C:8]1[O:7][N:6]=[C:5]([CH2:4][C:3]([NH:13][NH2:14])=[O:2])[CH:9]=1참가 물질
4
실험 절차
As described for example 112a, (5-methyl-isoxazol-3-yl)-acetic acid methyl ester in butanol was reacted with hydrazine hydrate (2 equivalents) and the resulting mixture was heated under reflux for 90 min. Evaporation of all volatiles afforded the title compound as a white solid (yield: 90%). 1H-NMR (300 MHz, DMSO): δ=2.36 (d, J=0.7 Hz, 3H), 3.39 (s, 2H), 4.25 (s, 2H), 6.13 (d, J=0.7 Hz, 1H), 9.27 (s, 1H).
후처리
- temperaturethe resulting mixture was heated
- temperatureunder reflux for 90 min
- customEvaporation of all volatiles
출처 및 근거
- ORD 기록
- ord-92db03ef5bef403a9021ddf50163f35d
- 출처 데이터셋
- uspto-grants-2009_03
- 특허 번호
- US07507729B2
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