Sodium hydride → HCID 66886384, 화합물

HRID 1787851

반응식

HRID 1787851 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]=[C:11]([CH3:13])[NH:10][N:9]=2)=[CH:4][CH:3]=1.Cl[CH2:15][CH2:16][C:17]([NH:20][C:21](=[O:27])[O:22][C:23]([CH3:26])([CH3:25])[CH3:24])([CH3:19])[CH3:18].[H-].[Na+]>CN1C(=O)N(C)CCC1.[I-].C([N+](CCCC)(CCCC)CCCC)CCC>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:12]=[C:11]([CH3:13])[N:10]([CH2:15][CH2:16][C:17]([NH:20][C:21](=[O:27])[O:22][C:23]([CH3:26])([CH3:25])[CH3:24])([CH3:19])[CH3:18])[N:9]=2)=[CH:6][CH:7]=1

참가 물질

6

반응물 3

HCID 24758Sodium hydrideHCID 431667563-(4-Fluoro-phenyl)-5-methyl-[1,2,4]triazoleHCID 57429079tert-butyl N-(4-chloro-2-methylbutan-2-yl)carbamate

생성물 1

HCID 66886384HCID 66886384, 화합물

시약·촉매·용매 2

HCID 67553Tetrabutylammonium Iodide촉매HCID 816462(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl-용매

실험 절차

5.88 g (33 mmol) of 3-(4-fluoro-phenyl)-5-methyl-[1,2,4]triazole are dissolved in 40 mL DMPU and reacted with 11.04 g (50 mmol) of tert.butyl (3-chloro-1,1-dimethyl-propyl)-carbamate, 1.59 g (40 mmol, 60%) of sodium hydride and 2.21 g (6 mmol) of tetrabutylammonium iodide in the manner described in P-1-c).

출처 및 근거

ORD 기록
ord-b2cc11185257469d8d38bfba1120cb56
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07511067B2

연결된 노트

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