Sodium hydride → HCID 66886112, 화합물

HRID 1787852

반응식

HRID 1787852 반응식
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]=[C:12]([CH3:14])[NH:11][N:10]=2)[CH:5]=[C:6]([F:8])[CH:7]=1.[H-].[Na+].Cl[CH2:18][CH2:19][C:20]([NH:23][C:24](=[O:30])[O:25][C:26]([CH3:29])([CH3:28])[CH3:27])([CH3:22])[CH3:21]>CN1C(=O)N(C)CCC1.[I-].C([N+](CCCC)(CCCC)CCCC)CCC>[F:8][C:6]1[CH:5]=[C:4]([C:9]2[N:13]=[C:12]([CH3:14])[N:11]([CH2:18][CH2:19][C:20]([NH:23][C:24](=[O:30])[O:25][C:26]([CH3:29])([CH3:28])[CH3:27])([CH3:22])[CH3:21])[N:10]=2)[CH:3]=[C:2]([F:1])[CH:7]=1

참가 물질

6

반응물 3

HCID 24758Sodium hydrideHCID 431668063-(3,5-Difluoro-phenyl)-5-methyl-[1,2,4]triazoleHCID 57429079tert-butyl N-(4-chloro-2-methylbutan-2-yl)carbamate

생성물 1

HCID 66886112HCID 66886112, 화합물

시약·촉매·용매 2

HCID 67553Tetrabutylammonium Iodide촉매HCID 816462(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl-용매

실험 절차

3.74 g (19 mmol) of 3-(3,5-difluoro-phenyl)-5-methyl-[1,2,4]triazole in 25 mL DMPU are reacted with 0.92 g (23 mmol, 60%) of sodium hydride, 6.37 g (29 mmol) of tert.butyl (3-chloro-1,1-dimethyl-propyl)-carbamate and 1.27 g (3.5 mmol) of tetrabutylammonium iodide analogously to P-1-c). Oil.

출처 및 근거

ORD 기록
ord-be8785509a74442a8b9d8d877d506d40
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07511067B2

연결된 노트

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