Hydrochloric Acid → 5-Amino-2-chloro-4-fluorophenylthioacetic acid

HRID 1788775노트

반응식

HRID 1788775 반응식
C([NH:4][C:5]1[C:6]([F:16])=[CH:7][C:8]([Cl:15])=[C:9]([CH2:11][C:12]([OH:14])=[S:13])[CH:10]=1)(=O)C.Cl.[OH-].[Na+]>>[NH2:4][C:5]1[C:6]([F:16])=[CH:7][C:8]([Cl:15])=[C:9]([CH2:11][C:12]([OH:14])=[S:13])[CH:10]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 1784742305-(N-acetylamino)-2-chloro-4-fluorophenylthioacetic acid

생성물 1

HCID 1785076495-Amino-2-chloro-4-fluorophenylthioacetic acid수율 73%

실험 절차

A suspension of 5-(N-acetylamino)-2-chloro-4-fluorophenylthioacetic acid (89.8 g) in a 10% aqueous hydrochloric acid solution was refluxed for 2 hours under heating. After being allowed to cool, an aqueous solution of sodium hydroxide was added to make the suspension at pH 4. After ice-cooling, the precipitated crystals were collected by filteration, washed with ice-water and dried to give 55.0 g of 5-amino-2-chloro-4-fluorophenylthioacetic acid.

후처리

  1. temperaturewas refluxed for 2 hours
  2. temperatureunder heating
  3. temperatureto cool
  4. temperatureAfter ice-cooling
  5. customthe precipitated crystals were collected by filteration
  6. washwashed with ice-water
  7. customdried

출처 및 근거

ORD 기록
ord-66918d79d0a84c83a3cb9be01a6051a0
출처 데이터셋
uspto-grants-1987_08
특허 번호
US04684397

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