Hydrochloric Acid → (4-Methoxy-6-Methyl-2-pyriMidinyl)thiourea, 97+%

HRID 1789287노트

반응식

HRID 1789287 반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[N:6]=[C:5]([NH:10][C:11]([NH:13]NC(=O)C2C=CC=CC=2)=[S:12])[N:4]=1.[OH-].[Na+].Cl>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[N:6]=[C:5]([NH:10][C:11]([NH2:13])=[S:12])[N:4]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 54321636HCID 54321636, 화합물

생성물 1

HCID 939981(4-Methoxy-6-Methyl-2-pyriMidinyl)thiourea, 97+%수율 102.5%

실험 절차

A mixture of 25 g of the compound from Example 3 and 55 ml of 10% aqueous sodium hydroxide was heated on the steam bath for 30 minutes, cooled, neutralized with aqueous HCl to pH 8, filtered, washed with water, dried by suction, and washed with ether to afford 16 g of the title compound, m.p. 220° d.

후처리

  1. temperaturewas heated on the steam bath for 30 minutes
  2. temperaturecooled
  3. filtrationfiltered
  4. washwashed with water
  5. customdried by suction
  6. washwashed with ether

출처 및 근거

ORD 기록
ord-a40805c7071b481f815b33baed5200e6
출처 데이터셋
uspto-grants-1987_08
특허 번호
US04689070

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