Hydrochloric Acid → (E)-1-(4-Chloro-1-butenyl)-4-fluorobenzene
반응식
[CH:1]1([CH:4]([C:6]2[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=2)O)[CH2:3][CH2:2]1.[ClH:13]>C(Cl)(Cl)Cl>[Cl:13][CH2:3][CH2:2]/[CH:1]=[CH:4]/[C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1참가 물질
4
실험 절차
Dissolve 12.8 g (0.077 mole) of α-cyclopropyl-4-fluorobenzenemethanol in 60 ml of CHCl3, add 20 ml of concentrated HCl and reflux overnight. Separate the two layers, and extract the aqueous layer with methylene chloride. Combine the methylene chloride extracts with the chloroform layer and wash with saturated aqueous sodium bicarbonate, and dry over magnesium sulfate. Evaporate the organic solvents to yield the title compound.
후처리
- temperaturereflux overnight
- customSeparate the two layers
- extractionextract the aqueous layer with methylene chloride
- washwash with saturated aqueous sodium bicarbonate
- dry with materialdry over magnesium sulfate
- customEvaporate the organic solvents
출처 및 근거
- ORD 기록
- ord-e683030b619748749d3b54d0c6f9699e
- 출처 데이터셋
- uspto-grants-1987_08
- 특허 번호
- US04689341
반응 노트
불러오는 중…