Hydrochloric Acid → 3-phenyl-6-(3-phenylpropyloxy)-1-oxo-1H-indene-2-carboxylate cyclohexylamide

3-Phenyl-6-(3-phenylpropyloxy)-1-oxo-1H-indene-2-carboxylate (200 mg, 0.52 mmol) was dissolved in dichloromethane (10 ml). Triethylamine (240 μl, 1.72 mmol) and cyclohexylamine (59 μl, 0.52 mmol) were added thereto at 10° C. Then, after adding bis(2-oxo-3-oxazolidinyl)phosphinic chloride (137 mg, 0.52 mmol), the reaction mixture was stirred for about 20 min at room temperature followed by additional 1 hour at 10° C. After the water was added thereto to complete the reaction, pH was adjusted to 1˜1.5 with 4N hydrochloric acid. The mixture was washed with brine, and extracted with dichloromethane. The extract was dried over anhydrous sulfonate sulfate, concentrated, and the resulting residue was purified by column chromatography (ethyl acetate:hexane=1:9˜2:8) to obtain the title compound (yield 59.8%) as a red solid.

1. customat 10° C
2. waitfollowed by additional 1 hour at 10° C
3. customthe reaction, pH
4. washThe mixture was washed with brine
5. extractionextracted with dichloromethane
6. dry with materialThe extract was dried over anhydrous sulfonate sulfate
7. concentrationconcentrated
8. customthe resulting residue was purified by column chromatography (ethyl acetate:hexane=1:9˜2:8)

ORD 기록

ord-b7a74c8b2c8249d2bb1e621f9135b741

출처 데이터셋

uspto-grants-2010_06

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US07741323B2